Studies of Parainfluenza Viruses
نویسندگان
چکیده
Serologic cross reactions have been demonstrated between members of the parainfluenza subgroup of myxoviruses.7'-Similar antigenic relationships have also been noted between mumps virus and each of the four parainfluenza virus serotyes" and between mumps and Newcastle disease virus.7'8 Furthermore, the DA virus, § a myxovirus recently isolated from human blood, which is serologically indistinguishable from the simian virus SV5, was found to be antigenically related to mumps virus.9 " This extensive degree of immunologic overlap between myxoviruses raises obvious problems in the interpretation of serologic tests. The purpose of the present study is to determine the specificity of serological reaction to the parainfluenza, mumps, DA, and Newcastle disease viruses (NDV) in humans under conditions of natural infection, and to assess the effect of antigenic crossing on the results obtained in paired sera and on serologic surveys of single samples of human sera. Antigenic crossing between these viruses in animals after immunization will be reported in a separate paper. MATERIALS AND METHODS Virus strains and antigen preparation Parainfluenza virus type 1 (strain 3512) and parainfluenza type 2 (strain 3668) were isolated in this laboratory.' Prototype strain C39 was used for parainfluenza type 3. These three types of parainfluenza viruses were grown in rhesus monkey kidney cell cultures using an acid medium containing Earle's salt solution, 0.07 per cent * Assistant Professor of Epidemiology.
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ورودعنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 35 شماره
صفحات -
تاریخ انتشار 1963